Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it is unclear whether loss of these ubiquitously important functions fully explains the c...

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Vydáno v:Nat Commun
Hlavní autoři: Zhang, Xiaowen, Chiang, Huai-Chin, Wang, Yao, Zhang, Chi, Smith, Sabrina, Zhao, Xiayan, Nair, Sreejith J., Michalek, Joel, Jatoi, Ismail, Lautner, Meeghan, Oliver, Boyce, Wang, Howard, Petit, Anna, Soler, Teresa, Brunet, Joan, Mateo, Francesca, Angel Pujana, Miguel, Poggi, Elizabeth, Chaldekas, Krysta, Isaacs, Claudine, Peshkin, Beth N., Ochoa, Oscar, Chedin, Frederic, Theoharis, Constantine, Sun, Lu-Zhe, Curiel, Tyler J., Elledge, Richard, Jin, Victor X., Hu, Yanfen, Li, Rong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490191/
https://ncbi.nlm.nih.gov/pubmed/28649985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15908
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