Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it is unclear whether loss of these ubiquitously important functions fully explains the c...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Zhang, Xiaowen, Chiang, Huai-Chin, Wang, Yao, Zhang, Chi, Smith, Sabrina, Zhao, Xiayan, Nair, Sreejith J., Michalek, Joel, Jatoi, Ismail, Lautner, Meeghan, Oliver, Boyce, Wang, Howard, Petit, Anna, Soler, Teresa, Brunet, Joan, Mateo, Francesca, Angel Pujana, Miguel, Poggi, Elizabeth, Chaldekas, Krysta, Isaacs, Claudine, Peshkin, Beth N., Ochoa, Oscar, Chedin, Frederic, Theoharis, Constantine, Sun, Lu-Zhe, Curiel, Tyler J., Elledge, Richard, Jin, Victor X., Hu, Yanfen, Li, Rong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490191/
https://ncbi.nlm.nih.gov/pubmed/28649985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15908
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