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What Controls the Hybridization Thermodynamics of Spherical Nucleic Acids?

The hybridization of free oligonucleotides to densely packed, oriented arrays of DNA modifying the surfaces of spherical nucleic acid (SNA)–gold nanoparticle conjugates occurs with negative cooperativity; i.e., each binding event destabilizes subsequent binding events. DNA hybridization is thus an e...

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Publicado en:J Am Chem Soc
Autores principales: Randeria, Pratik S., Jones, Matthew R., Kohlstedt, Kevin L., Banga, Resham J., de la Cruz, Monica Olvera, Schatz, George C., Mirkin, Chad A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490082/
https://ncbi.nlm.nih.gov/pubmed/25738968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b00670
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