Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation

Transendothelial cell macroaperture (TEM) tunnels control endothelium barrier function and are triggered by several toxins from pathogenic bacteria that provoke vascular leakage. Cellular dewetting theory predicted that a line tension of uncharacterized origin works at TEM boundaries to limit their...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Stefani, Caroline, Gonzalez-Rodriguez, David, Senju, Yosuke, Doye, Anne, Efimova, Nadia, Janel, Sébastien, Lipuma, Justine, Tsai, Meng Chen, Hamaoui, Daniel, Maddugoda, Madhavi P., Cochet-Escartin, Olivier, Prévost, Coline, Lafont, Frank, Svitkina, Tatyana, Lappalainen, Pekka, Bassereau, Patricia, Lemichez, Emmanuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490010/
https://ncbi.nlm.nih.gov/pubmed/28643776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15839
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