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Impaired vasodilation by red blood cells in sickle cell disease
Red blood cells (RBCs) have been ascribed a unique role in dilating blood vessels, which requires O(2)-regulated binding and bioactivation of NO by Hb and transfer of NO equivalents to the RBC membrane. Vasoocclusion in hypoxic tissues is the hallmark of sickle cell anemia. Here we show that sickle...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2005
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548996/ https://ncbi.nlm.nih.gov/pubmed/15699345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409876102 |
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