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A Routine ‘Top-Down’ Approach to Analysis of the Human Serum Proteome

Serum provides a rich source of potential biomarker proteoforms. One of the major obstacles in analysing serum proteomes is detecting lower abundance proteins owing to the presence of hyper-abundant species (e.g., serum albumin and immunoglobulins). Although depletion methods have been used to addre...

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Bibliographic Details
Published in:Proteomes
Main Authors: D’Silva, Arlene M., Hyett, Jon A., Coorssen, Jens R.
Format: Artigo
Language:Inglês
Published: MDPI 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489773/
https://ncbi.nlm.nih.gov/pubmed/28587287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/proteomes5020013
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