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Convergent signaling by acidosis and receptor activator of NF-κB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts

Systemic acidosis has detrimental effects on the skeleton, and local acidosis coincides with bone destruction in inflammatory and metastatic diseases. Acidification dramatically enhances osteoclastic resorption, although the underlying mechanism has remained elusive. We investigated the effect of ac...

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Detalhes bibliográficos
Main Authors: Komarova, Svetlana V., Pereverzev, Alexey, Shum, Jonathan W., Sims, Stephen M., Dixon, S. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC548977/
https://ncbi.nlm.nih.gov/pubmed/15695591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406874102
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