Immunization with Toxoplasma gondii GRA17 Deletion Mutant Induces Partial Protection and Survival in Challenged Mice

Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a ΔGRA17 mutant by disrupting the virulence factor GRA17 using CRISPR-Cas9 method. Then, we tested whether ΔGRA17 tachyzoites can be used as a live-attenuated vaccine against...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Wang, Jin-Lei, Elsheikha, Hany M., Zhu, Wei-Ning, Chen, Kai, Li, Ting-Ting, Yue, Dong-Mei, Zhang, Xiao-Xuan, Huang, Si-Yang, Zhu, Xing-Quan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489627/
https://ncbi.nlm.nih.gov/pubmed/28706518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00730
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