The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages.

The human immunodeficiency virus (HIV) genetic determinant(s) responsible for tropism in human T cells or macrophages are not well defined. We studied the role of the HIV type 2 (HIV-2) nef and vpr genes in viral tropism. HIV-2 mutants, lacking either vpr or nef genes, or both vpr and nef, were obta...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hattori, N, Michaels, F, Fargnoli, K, Marcon, L, Gallo, R C, Franchini, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54896/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2236020/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.20.8080
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