The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo

Glucagon like peptide-1 (GLP-1) plays a vital role in glucose homeostasis and sustaining β-cell function. Currently there are two major methods to enhance endogenous GLP-1 activity; inhibiting dipeptidyl peptidase-4 (DPP4) or activating G protein-coupled receptor 119 (GPR119). Here we describe and v...

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Publicado no:Sci Rep
Main Authors: Huan, Yi, Jiang, Qian, Li, Gang, Bai, Guoliang, Zhou, Tian, Liu, Shuainan, Li, Caina, Liu, Quan, Sun, Sujuan, Yang, Miaomiao, Guo, Nan, Wang, Xing, Wang, Shusen, Liu, Yaojuan, Wang, Guanqiao, Huang, Haihong, Shen, Zhufang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489512/
https://ncbi.nlm.nih.gov/pubmed/28659588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04633-5
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