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Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or translational level. We disrupted the dicer-1 (dcr-1) gene in mouse embryonic stem (ES) cells by condi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548949/ https://ncbi.nlm.nih.gov/pubmed/15713842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1248505 |
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