A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

Only one out of 10 drugs in development passes clinical trials. Many fail because experimental animal models poorly predict human xenobiotic metabolism. Human liver chimeric mice are a step forward in this regard, as the human hepatocytes in chimeric livers generate human metabolites, but the remain...

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Publicat a:Nat Commun
Autors principals: Barzi, Mercedes, Pankowicz, Francis P., Zorman, Barry, Liu, Xing, Legras, Xavier, Yang, Diane, Borowiak, Malgorzata, Bissig-Choisat, Beatrice, Sumazin, Pavel, Li, Feng, Bissig, Karl-Dimiter
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489481/
https://ncbi.nlm.nih.gov/pubmed/28659616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00049-x
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