PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis

The histone methyl transferase PR-Set7 mediates histone H4 Lys 20 methylation, a mark of constitutive and facultative heterochromatin. We isolated a null mutation in Drosophila PR-Set7 that suppresses position effect variegation, indicating that PR-Set7 indeed functions in silencing general gene exp...

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Main Authors: Karachentsev, Dmitry, Sarma, Kavitha, Reinberg, Danny, Steward, Ruth
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2005
主題:
Research Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC548943/
https://ncbi.nlm.nih.gov/pubmed/15681608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1263005
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