Patients with colorectal cancer associated with Lynch syndrome and MLH1 promoter hypermethylation have similar prognoses

PURPOSE: Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by Lynch syndrome (LS) in 3% and sporadic inactivation of MLH1 by hypermethylation (MLH1-hm) in 12% of CRC cases. It is not clear whether outcomes between LS-associated and MLH1-hm CRC differ. The objective of this study was...

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Vydáno v:Genet Med
Hlavní autoři: Haraldsdottir, Sigurdis, Hampel, Heather, Wu, Christina, Weng, Daniel Y., Shields, Peter G., Frankel, Wendy L., Pan, Xueliang, de la Chapelle, Albert, Goldberg, Richard M, Bekaii-Saab, Tanios
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489337/
https://ncbi.nlm.nih.gov/pubmed/26866578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2015.184
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