The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn’s disease

Fibrosis is the result of dysregulated tissue regeneration and is characterized by excessive accumulation of matrix proteins that become detrimental to tissue function. In Crohn’s disease, this manifests itself as recurrent gastrointestinal strictures for which there is no effective therapy beyond s...

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Bibliographic Details
Published in:Sci Immunol
Main Authors: Lo, Bernard C., Gold, Matthew J., Hughes, Michael R., Antignano, Frann, Valdez, Yanet, Zaph, Colby, Harder, Kenneth W., McNagny, Kelly M.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489332/
https://ncbi.nlm.nih.gov/pubmed/28670633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaf8864
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