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The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn’s disease

Fibrosis is the result of dysregulated tissue regeneration and is characterized by excessive accumulation of matrix proteins that become detrimental to tissue function. In Crohn’s disease, this manifests itself as recurrent gastrointestinal strictures for which there is no effective therapy beyond s...

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Détails bibliographiques
Publié dans:Sci Immunol
Auteurs principaux: Lo, Bernard C., Gold, Matthew J., Hughes, Michael R., Antignano, Frann, Valdez, Yanet, Zaph, Colby, Harder, Kenneth W., McNagny, Kelly M.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489332/
https://ncbi.nlm.nih.gov/pubmed/28670633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaf8864
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