Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between varianc...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Shungin, Dmitry, Deng, Wei Q., Varga, Tibor V., Luan, Jian'an, Mihailov, Evelin, Metspalu, Andres, Morris, Andrew P., Forouhi, Nita G., Lindgren, Cecilia, Magnusson, Patrik K. E., Pedersen, Nancy L., Hallmans, Göran, Chu, Audrey Y., Justice, Anne E., Graff, Mariaelisa, Winkler, Thomas W., Rose, Lynda M., Langenberg, Claudia, Cupples, L. Adrienne, Ridker, Paul M., Wareham, Nicholas J., Ong, Ken K., Loos, Ruth J. F., Chasman, Daniel I., Ingelsson, Erik, Kilpeläinen, Tuomas O., Scott, Robert A., Mägi, Reedik, Paré, Guillaume, Franks, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489225/
https://ncbi.nlm.nih.gov/pubmed/28614350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006812
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