Pulmonary alveolar macrophages from patients with active sarcoidosis express type IV collagenolytic proteinase. An enzymatic mechanism for influx of mononuclear phagocytes at sites of disease activity.

Alveolar macrophages (AMs) recovered from the bronchoalveolar lavage (BAL) of 44 patients with sarcoidosis were evaluated for their ability to release type IV collagenolytic metalloproteinase (IV-Case). This enzyme, which is produced by peripheral blood monocytes (PBMs) but not by tissue macrophages...

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Publicado en:J Clin Invest
Autores principales: Agostini, C, Garbisa, S, Trentin, L, Zambello, R, Fastelli, G, Onisto, M, Cipriani, A, Festi, G, Casara, D, Semenzato, G
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1989
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548922/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2668335/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114205
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