Pulmonary alveolar macrophages from patients with active sarcoidosis express type IV collagenolytic proteinase. An enzymatic mechanism for influx of mononuclear phagocytes at sites of disease activity.

Alveolar macrophages (AMs) recovered from the bronchoalveolar lavage (BAL) of 44 patients with sarcoidosis were evaluated for their ability to release type IV collagenolytic metalloproteinase (IV-Case). This enzyme, which is produced by peripheral blood monocytes (PBMs) but not by tissue macrophages...

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Detalhes bibliográficos
Main Authors: Agostini, C, Garbisa, S, Trentin, L, Zambello, R, Fastelli, G, Onisto, M, Cipriani, A, Festi, G, Casara, D, Semenzato, G
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC548922/
https://ncbi.nlm.nih.gov/pubmed/2668335
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