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Reversible perturbations of gene regulation after genome editing in Drosophila cells

The prokaryotic phage defense CRISPR/cas-system has developed into a versatile toolbox for genome engineering and genetic studies in many organisms. While many efforts were spent on analyzing the consequences of off-target effects, only few studies addressed side-effects that occur due to the target...

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Pubblicato in:PLoS One
Autori principali: Kunzelmann, Stefan, Förstemann, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489201/
https://ncbi.nlm.nih.gov/pubmed/28658280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180135
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