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Path from schizophrenia genomics to biology: gene regulation and perturbation in neurons derived from induced pluripotent stem cells and genome editing

Schizophrenia (SZ) is a devastating mental disorder afflicting 1% of the population. Recent genome-wide association studies (GWASs) of SZ have identified >100 risk loci. However, the causal variants/genes and the causal mechanisms remain largely unknown, which hinders the translation of GWAS find...

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Bibliografske podrobnosti
izdano v:Neurosci Bull
Glavni avtor: Duan, Jubao
Format: Artigo
Jezik:Inglês
Izdano: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332546/
https://ncbi.nlm.nih.gov/pubmed/25575480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-014-1488-2
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