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MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy
The “super-relaxed state” (SRX) of myosin represents a ‘reserve’ of motors in the heart. Myosin heads in the SRX are bound to the thick filament and have a very low ATPase rate. Changes in the SRX are likely to modulate cardiac contractility. We previously demonstrated that the SRX is significantly...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5489194/ https://ncbi.nlm.nih.gov/pubmed/28658286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180064 |
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