MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

The “super-relaxed state” (SRX) of myosin represents a ‘reserve’ of motors in the heart. Myosin heads in the SRX are bound to the thick filament and have a very low ATPase rate. Changes in the SRX are likely to modulate cardiac contractility. We previously demonstrated that the SRX is significantly...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: McNamara, James W., Li, Amy, Lal, Sean, Bos, J. Martijn, Harris, Samantha P., van der Velden, Jolanda, Ackerman, Michael J., Cooke, Roger, dos Remedios, Cristobal G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489194/
https://ncbi.nlm.nih.gov/pubmed/28658286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180064
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