Recombinant plasminogen activator inhibitor-1 reverses the bleeding tendency associated with the combined administration of tissue-type plasminogen activator and aspirin in rabbits.

The major side effect of thrombolytic therapy is bleeding; however, the pathogenesis of this potential complication is not well understood. Accordingly, we examined the effects of aspirin and recombinant human tissue-type plasminogen activator (rt-PA) on serial template bleeding times and on hemosta...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Vaughan, D E, Declerck, P J, De Mol, M, Collen, D
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548919/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2503540/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114202
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