Genetic Variation at the PCSK9 Locus Moderately Lowers Low Density Lipoprotein Cholesterol Levels, But Does Not Significantly Lower Vascular Disease Risk in an Elderly Population

Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk. Our objective was to examine two PCSK9 single nucle...

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Detalhes bibliográficos
Publicado no:Atherosclerosis
Main Authors: Polisecki, Eliana, Peter, Inga, Robertson, Michele, McMahon, Alex D, Ford, Ian, Packard, Christopher, Shepherd, James, Jukema, J Wouter, Blauw, Gerard J., Westendorp, Rudi G. J., de Craen, Anton J. M., Trompet, Stella, Buckley, Brendan M., Murphy, Michael B., Ordovas, Jose M., Schaefer, Ernst J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489067/
https://ncbi.nlm.nih.gov/pubmed/18262190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2007.12.005
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