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Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues

Water-soluble bioadhesive polymers bearing multiple guanidinium ion (Gu(+)) pendants at their side-chain termini (Glue(n)–BA, n = 10 and 29) that were conjugated with benzamidine (BA) as a trypsin inhibitor were developed. The Glue(n)–BA molecules are supposed to adhere to oxyanionic regions of the...

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Detaylı Bibliyografya
Yayımlandı:Chem Sci
Asıl Yazarlar: Mogaki, Rina, Okuro, Kou, Aida, Takuzo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489047/
https://ncbi.nlm.nih.gov/pubmed/28706668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc00524h
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