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Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs

Osteocyte apoptosis is essential to activate bone remodeling in response to fatigue microdamage and estrogen withdrawal, such that apoptosis inhibition in vivo prevents the onset of osteoclastic resorption. Osteocyte apoptosis has also been spatially linked to bone resorption owing to disuse, but wh...

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Библиографические подробности
Опубликовано в: :J Bone Miner Res
Главные авторы: Cabahug-Zuckerman, Pamela, Frikha-Benayed, Dorra, Majeska, Robert J, Tuthill, Alyssa, Yakar, Shoshana, Judex, Stefan, Schaffler, Mitchell B
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488280/
https://ncbi.nlm.nih.gov/pubmed/26852281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2807
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