Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production

Central nervous system infection of neonatal and adult rats with Borna disease virus (BDV) results in neuronal destruction and behavioral abnormalities with differential immune-mediated involvement. Neuroactive metabolites generated from the kynurenine pathway of tryptophan degradation have been imp...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Virol
Päätekijät: Formisano, Simone, Hornig, Mady, Yaddanapudi, Kavitha, Vasishtha, Mansi, Parsons, Loren H., Briese, Thomas, Lipkin, W. Ian, Williams, Brent L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2017
Aiheet:
Cellular Response to Infection
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487560/
https://ncbi.nlm.nih.gov/pubmed/28446679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00673-17
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