Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production

Central nervous system infection of neonatal and adult rats with Borna disease virus (BDV) results in neuronal destruction and behavioral abnormalities with differential immune-mediated involvement. Neuroactive metabolites generated from the kynurenine pathway of tryptophan degradation have been imp...

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Publicat a:J Virol
Autors principals: Formisano, Simone, Hornig, Mady, Yaddanapudi, Kavitha, Vasishtha, Mansi, Parsons, Loren H., Briese, Thomas, Lipkin, W. Ian, Williams, Brent L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Cellular Response to Infection
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487560/
https://ncbi.nlm.nih.gov/pubmed/28446679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00673-17
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