CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8(+) T(EM) and CD8(+) T(RM) Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease

Herpes simplex virus 1 (HSV-1) establishes latency within the sensory neurons of the trigeminal ganglia (TG). HSV-specific memory CD8(+) T cells play a critical role in preventing HSV-1 reactivation from TG and subsequent virus shedding in tears that trigger recurrent corneal herpetic disease. The C...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Srivastava, Ruchi, Khan, Arif A., Chilukuri, Sravya, Syed, Sabrina A., Tran, Tien T., Furness, Julie, Bahraoui, Elmostafa, BenMohamed, Lbachir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487556/
https://ncbi.nlm.nih.gov/pubmed/28468883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00278-17
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