The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth

The long-term integrity of an articulating joint is dependent upon the nourishment of its cartilage component and the protection of the cartilage surface from friction-induced wear. Loss-of-function mutations in lubricin (a secreted glycoprotein encoded by the gene PRG4) cause the human autosomal re...

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Detalhes bibliográficos
Main Authors: Rhee, David K., Marcelino, Jose, Baker, MacArthur, Gong, Yaoqin, Smits, Patrick, Lefebvre, Véronique, Jay, Gregory D., Stewart, Matthew, Wang, Hongwei, Warman, Matthew L., Carpten, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC548698/
https://ncbi.nlm.nih.gov/pubmed/15719068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522263
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