MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene

To improve radiation therapy-induced quality of life impairments for prostate cancer patients, the development of radio-protectors is needed. Our previous work has demonstrated that MnTE-2-PyP significantly protects urogenital tissues from radiation-induced damage. So, in order for MnTE-2-PyP to be...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Tong, Qiang, Weaver, Michael R., Kosmacek, Elizabeth A., O’Connor, Brian, Harmacek, Laura, Venkataraman, Sujatha, Oberley-Deegan, Rebecca E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486868/
https://ncbi.nlm.nih.gov/pubmed/26944191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.02.036
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