Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab

PURPOSE: A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating that combined KIT and CTLA-4 blockade is synergistic. EXPERIMENTAL DESIGN: A standard 3 + 3 design was used to...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: D'Angelo, Sandra P., Shoushtari, Alexander N., Keohan, Mary Louise, Dickson, Mark A., Gounder, Mrinal M., Chi, Ping, Loo, Jennifer K., Gaffney, Leigh, Schneider, Lee, Patel, Zarine, Erinjeri, Joseph Patrick, Bluth, Mark J., Sjoberg, Ana, Streicher, Howard, Takebe, Naoko, Qin, Li-Xuan, Antonescu, Cristina, DeMatteo, Ronald P., Carvajal, Richard D., Tap, William D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486863/
https://ncbi.nlm.nih.gov/pubmed/28007774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2349
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