The loss of NKX3.1 expression in testicular – and prostate – cancers is not caused by promoter hypermethylation

BACKGROUND: Recent studies have demonstrated that the NKX3.1 protein is commonly down-regulated in testicular germ cell tumors (TGCTs) and prostate carcinomas. The homeobox gene NKX3.1 maps to chromosome band 8p21, which is a region frequently lost in prostate cancer, but not in TGCT. Mutations have...

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Main Authors: Lind, Guro E, Skotheim, Rolf I, Fraga, Mario F, Abeler, Vera M, Henrique, Rui, Saatcioglu, Fahri, Esteller, Manel, Teixeira, Manuel R, Lothe, Ragnhild A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2005
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC548671/
https://ncbi.nlm.nih.gov/pubmed/15691383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-4-8
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