The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles

Cyclin E, an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression in metazoans and is frequently overexpressed in cancer cells. It is essential for entry to the cell cycle from G0 quiescent phase, for the assembly of prereplication complexes and for endoreduplication in megakar...

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Bibliographic Details
Main Authors: Honda, Reiko, Lowe, Edward D, Dubinina, Elena, Skamnaki, Vicky, Cook, Atlanta, Brown, Nick R, Johnson, Louise N
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC548659/
https://ncbi.nlm.nih.gov/pubmed/15660127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600554
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