B-cell non-Hodgkin lymphoma: Selective vulnerability to PIKFYVE inhibition

We identified the PIKFYVE inhibitor apilimod as a potent and selective cytotoxic agent against B-cell non-Hodgkin lymphoma (B-NHL). Our data robustly establish PIKFYVE as the target through which apilimod kills B-NHL cells and show that apilimod-induced death in B-NHL is mediated by broad disruption...

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Udgivet i:Autophagy
Main Authors: Gayle, Sophia, Landrette, Sean, Beeharry, Neil, Conrad, Chris, Hernandez, Marylens, Beckett, Paul, Ferguson, Shawn M., Xu, Tian, Rothberg, Jonathan, Lichenstein, Henri
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Autophagic Punctum
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486370/
https://ncbi.nlm.nih.gov/pubmed/28350209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1304871
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