MYCN is an immunosuppressive oncogene dampening the expression of ligands for NK-cell-activating receptors in human high-risk neuroblastoma

Neuroblastoma (NB) is the most common extracranial solid tumor occurring in childhood. Amplification of the MYCN oncogene is associated with poor prognosis. Downregulation on NB cells of ligands recognized by Natural Killer (NK) cell-activating receptors, involved in tumor cell recognition and lysis...

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Publicat a:Oncoimmunology
Autors principals: Brandetti, Elisa, Veneziani, Irene, Melaiu, Ombretta, Pezzolo, Annalisa, Castellano, Aurora, Boldrini, Renata, Ferretti, Elisa, Fruci, Doriana, Moretta, Lorenzo, Pistoia, Vito, Locatelli, Franco, Cifaldi, Loredana
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2017
Matèries:
Brief Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486189/
https://ncbi.nlm.nih.gov/pubmed/28680748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1316439
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