Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling

PTP1B and TC-PTP are highly related protein-tyrosine phosphatases (PTPs) that regulate the JAK/STAT signaling cascade essential for cytokine-receptor activation in immune cells. Here, we describe a novel immunotherapy approach whereby monocyte-derived dendritic cell (moDC) function is enhanced by mo...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Penafuerte, Claudia, Feldhammer, Matthew, Mills, John R., Vinette, Valerie, Pike, Kelly A., Hall, Anita, Migon, Eva, Karsenty, Gerard, Pelletier, Jerry, Zogopoulos, George, Tremblay, Michel L.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486178/
https://ncbi.nlm.nih.gov/pubmed/28680757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1321185
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