Design and Synthesis of Non-Peptide Mimetics Mapping the Immunodominant Myelin Basic Protein (MBP(83–96)) Epitope to Function as T-Cell Receptor Antagonists

Encephalitogenic T cells are heavily implicated in the pathogenesis of multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system. Their stimulation is triggered by the formation of a trimolecular complex between the human leukocyte antigen (HLA), an immunodominant my...

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Pubblicato in:Int J Mol Sci
Autori principali: Yannakakis, Mary-Patricia, Simal, Carmen, Tzoupis, Haralambos, Rodi, Maria, Dargahi, Narges, Prakash, Monica, Mouzaki, Athanasia, Platts, James A., Apostolopoulos, Vasso, Tselios, Theodore V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486038/
https://ncbi.nlm.nih.gov/pubmed/28594344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18061215
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