DNA-PK promotes the mitochondrial, metabolic and physical decline that occurs during aging

Hallmarks of aging that negatively impact health include weight gain and reduced physical fitness, which can increase insulin resistance and risk for many diseases including type 2 diabetes. The underlying mechanism(s) for these phenomena is poorly understood. Here we report that aging increases DNA...

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Publicado no:Cell Metab
Main Authors: Park, Sung-Jun, Gavrilova, Oksana, Brown, Alexandra L., Soto, Jamie E., Bremner, Shannon, Kim, Jeonghan, Xu, Xihui, Yang, Shutong, Um, Jee-Hyun, Koch, Lauren G., Britton, Steven L., Lieber, Richard L., Philp, Andrew, Baar, Keith, Kohama, Steven G., Abel, E. Dale, Kim, Myung K., Chung, Jay H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485859/
https://ncbi.nlm.nih.gov/pubmed/28467930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.04.008
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