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Potentiation of the ligand-binding activity of integrin α3β1 via association with tetraspanin CD151

CD151, one of the tetraspanins, forms a stable complex with integrin α3β1, the major laminin receptor on the cell surface. We found that 8C3, an anti-CD151 mAb obtained by screening for reactivity with integrin α3β1–CD151 complexes, was capable of dissociating CD151 from integrin α3β1, thereby allow...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Nishiuchi, Ryoko, Sanzen, Noriko, Nada, Shigeyuki, Sumida, Yasuhiro, Wada, Yoshinao, Okada, Masato, Takagi, Junichi, Hasegawa, Hitoshi, Sekiguchi, Kiyotoshi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548567/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15677332/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0409493102
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