A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia–reperfusion injury

The cytokine erythropoietin (EPO) protects the heart from ischemic injury, in part by preventing apoptosis. However, EPO administration can also raise the hemoglobin concentration, which, by increasing oxygen delivery, confounds assignment of cause and effect. The availability of EPO analogs that do...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Fiordaliso, Fabio, Chimenti, Stefano, Staszewsky, Lidia, Bai, Antonio, Carlo, Eleonora, Cuccovillo, Ivan, Doni, Mirko, Mengozzi, Manuela, Tonelli, Rossella, Ghezzi, Pietro, Coleman, Thomas, Brines, Michael, Cerami, Anthony, Latini, Roberto
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548534/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15671158/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0409329102
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