ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype

OBJECTIVE: Obesity variably disrupts human health, but molecular-based patients' health-risk stratification is limited. Adipose tissue (AT) stresses may link obesity with metabolic dysfunction, but how they signal in humans remains poorly-characterized. We hypothesized that a transcriptional AT...

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Bibliografski detalji
Izdano u:Mol Metab
Glavni autori: Haim, Yulia, Blüher, Matthias, Konrad, Daniel, Goldstein, Nir, Klöting, Nora, Harman-Boehm, Ilana, Kirshtein, Boris, Ginsberg, Doron, Tarnovscki, Tanya, Gepner, Yftach, Shai, Iris, Rudich, Assaf
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2017
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485239/
https://ncbi.nlm.nih.gov/pubmed/28702328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.05.003
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