Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1

Autophagy genes' expression is upregulated in visceral fat in human obesity, associating with obesity-related cardio-metabolic risk. E2F1 (E2F transcription factor 1) was shown in cancer cells to transcriptionally regulate autophagy. We hypothesize that E2F1 regulates adipocyte autophagy in obe...

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Veröffentlicht in:Autophagy
Hauptverfasser: Haim, Yulia, Blüher, Matthias, Slutsky, Noa, Goldstein, Nir, Klöting, Nora, Harman-Boehm, Ilana, Kirshtein, Boris, Ginsberg, Doron, Gericke, Martin, Guiu Jurado, Esther, Kovsan, Julia, Tarnovscki, Tanya, Kachko, Leonid, Bashan, Nava, Gepner, Yiftach, Shai, Iris, Rudich, Assaf
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Clinical Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824599/
https://ncbi.nlm.nih.gov/pubmed/26391754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1094597
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