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Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL
The hypoxia-regulated tumor-suppressor von Hippel-Lindau (VHL) is an E3 ligase that recognizes its substrates as part of an oxygen-dependent prolyl hydroxylase (PHD) reaction, with hypoxia-inducible factor α (HIFα) being its most notable substrate. Here we report that VHL has an equally important fu...
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| Izdano u: | Oncogene |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5485216/ https://ncbi.nlm.nih.gov/pubmed/28114281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.495 |
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