The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis

Linear ubiquitination is a key posttranslational modification that regulates immune signaling and cell death pathways, notably tumor necrosis factor receptor 1 (TNFR1) signaling. The only known enzyme complex capable of forming linear ubiquitin chains under native conditions to date is the linear ub...

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Publicado en:Hepatology
Autores principales: Shimizu, Yutaka, Peltzer, Nieves, Sevko, Alexandra, Lafont, Elodie, Sarr, Aida, Draberova, Helena, Walczak, Henning
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Hepatobiliary Malignancies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485060/
https://ncbi.nlm.nih.gov/pubmed/28120397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29074
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