Nuclear Magnetic Resonance (NMR) Study for the Detection and Quantitation of Cholesterol in HSV529 Therapeutic Vaccine Candidate

This study describes the NMR-based method to determine the limit of quantitation (LOQ) and limit of detection (LOD) of cholesterol, a process-related impurity in the replication-deficient Herpes Simplex Virus (HSV) type 2 candidate vaccine HSV529. Three signature peaks from the 1D (1)H NMR of a chol...

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Bibliografiske detaljer
Udgivet i:Comput Struct Biotechnol J
Main Authors: Khatun, Rahima, Hunter, Howard, Magcalas, Webster, Sheng, Yi, Carpick, Bruce, Kirkitadze, Marina
Format: Artigo
Sprog:Inglês
Udgivet: Research Network of Computational and Structural Biotechnology 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484764/
https://ncbi.nlm.nih.gov/pubmed/28694932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2016.10.007
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