Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

RIG-I is a key cytosolic pattern recognition receptor that interacts with MAVS to induce type I interferons (IFNs) against RNA virus infection. In this study, we found that cyclophilin A (CypA), a peptidyl-prolyl cis/trans isomerase, functioned as a critical positive regulator of RIG-I-mediated anti...

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Veröffentlicht in:eLife
Hauptverfasser: Liu, Wei, Li, Jing, Zheng, Weinan, Shang, Yingli, Zhao, Zhendong, Wang, Shanshan, Bi, Yuhai, Zhang, Shuang, Xu, Chongfeng, Duan, Ziyuan, Zhang, Lianfeng, Wang, Yue L, Jiang, Zhengfan, Liu, Wenjun, Sun, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484619/
https://ncbi.nlm.nih.gov/pubmed/28594325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24425
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