Vascular PPARγ Controls Circadian Variation of Blood Pressure and Heart Rate via Activation of Bmal1

Thiazolidinediones (TZDs) are PPARγ activators that exhibit vasculoprotective properties. To determine the vascular function of PPARγ, we analyzed Tie2Cre/flox and SM22Cre/flox mice. Unexpectedly, both knockout strains exhibited a significant reduction of circadian variations in blood pressure and h...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Wang, Ningning, Yang, Guangrui, Jia, Zhanjun, Zhang, Hui, Aoyagi, Toshinori, Soodvilai, Sunhapas, Symons, J. David, Schnermann, Jurgen B., Gonzalez, Frank J., Litwin, Sheldon E., Yang, Tianxin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484540/
https://ncbi.nlm.nih.gov/pubmed/19041764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.10.009
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