Role of adipose tissue endothelial ADAM17 in age-related coronary microvascular dysfunction

OBJECTIVE: A disintegrin and metalloproteinase ADAM17 (TNF-α converting enzyme) regulates soluble TNF levels. We tested the hypothesis that aging-induced activation in adipose tissue (AT)-expressed ADAM17 contributes to the development of remote coronary microvascular dysfunction (CMD) in obesity. A...

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Bibliographic Details
Published in:Arterioscler Thromb Vasc Biol
Main Authors: Dou, Huijuan, Feher, Attila, Davila, Alec C, Romero, Maritza J, Patel, Vijay S, Kamath, Vinayak M, Gooz, Monika Beck, Rudic, R Daniel, Lucas, Rudolf, Fulton, David J, Weintraub, Neal L, Bagi, Zsolt
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484536/
https://ncbi.nlm.nih.gov/pubmed/28473444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309430
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