Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23

p23 is a small acidic protein with intrinsic molecular chaperone activity. It is best known as a co-chaperone of the major cytosolic molecular chaperone Hsp90. p23 binds the N-terminus of Hsp90 and stabilizes the ATP-bound and N-terminally closed Hsp90 dimer. It is in this configuration that many Hs...

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Publicat a:PLoS One
Autors principals: Madon-Simon, Marta, Grad, Iwona, Bayo, Pilar, Pérez, Paloma, Picard, Didier
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484504/
https://ncbi.nlm.nih.gov/pubmed/28650975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180035
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